ENGINEERING OF HELICOBACTER PYLORI L-ASPARAGINASE: CHARACTERIZATION OF TWO FUNCTIONALLY DISTINCT GROUPS OF MUTANTS.

Bacterial L-asparaginases have been used as anti-cancer drugs for over 4 decades though presenting, along with their therapeutic efficacy, several side effects due to their bacterial origin and, seemingly, to their secondary glutaminase activity.Helicobacter pylori type II L-asparaginase possesses interesting features, among which a reduced catalyt

Background: Although preclinical models reveal the neurobiological pathways altered through opioid abuse, comprehensive assessments of gene expression in human brain samples are needed.Moreover, less is known about gene expression in response to fatal overdose.The primary goal of the present study was to compare Midtown Crossbody gene expression in